eicosenoylcarnitine (c20:1)* to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs2108622

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.164
Position:
15990431
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
8.443
Reference Allele:
C
-log10(P):
-38.018
MAF:
0.298
Beta (Num):
0.070
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.094
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acylcarnitine)5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect a shift between fatty acid beta-oxidation and omega-oxidation, potentially influenced by CYP4F2's role in fatty acid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 function may alter fatty acid metabolism, contributing to an unfavorable lipid profile and increasing the risk of coronary atherosclerosis and ischemic heart disease.10[1], 11[2]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data