eicosenoylcarnitine (c20:1)* to hexadecenedioate (c16:1-dc)*

Numerator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Denominator Metabolite

Structure of hexadecenedioate (c16:1-dc)*
Metabolite Accession: GCST90200164
Name: hexadecenedioate (c16:1-dc)*
Hmdb Id: HMDB0304377
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs2108622

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.151
Position:
15990431
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
7.500
Reference Allele:
C
-log10(P):
-30.385
MAF:
0.298
Beta (Num):
0.070
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.081
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

A decreased CYP4F2 function could lead to accumulation of its substrate, eicosenoylcarnitine, and reduced production of downstream metabolites like hexadecenedioate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity, indicated by an increased ratio, may impair the breakdown of pro-inflammatory molecules and alter fatty acid metabolism, contributing to the inflammatory processes inherent in coronary atherosclerosis and ischemic heart disease.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data