eicosenoylcarnitine (c20:1)* to octadecenedioate (c18:1-dc)

Numerator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Denominator Metabolite

Structure of octadecenedioate (c18:1-dc)
Metabolite Accession: GCST90200165
Name: octadecenedioate (c18:1-dc)
Hmdb Id: HMDB0304442
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDPSQMGOAILWPE

Associated Genomic Regions

Region: rs2108622

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.233
Position:
15990431
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
11.493
Reference Allele:
C
-log10(P):
-68.714
MAF:
0.298
Beta (Num):
0.070
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.162
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.5[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, dicarboxylic acid metabolism.3[1], 6[2]

Ratio Explanation:

This ratio may reflect a balance between fatty acid beta-oxidation (numerator) and omega-oxidation (denominator), a pathway in which the enzyme CYP4F2 participates.2[1], 3[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A functional variant in CYP4F2, an enzyme linked to coronary heart disease, alters fatty acid metabolism.7[1], 8[2], 9[3] This dysregulation, reflected by the ratio, likely contributes to the pathogenesis of coronary atherosclerosis through its role in lipid metabolism and inflammation.2[4], 10[5]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data