eicosenoylcarnitine (c20:1)* to n-acetyl-2-aminooctanoate*

Numerator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Denominator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Associated Genomic Regions

Region: rs12317268

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.210
Position:
21352541
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
7.857
Reference Allele:
A
-log10(P):
-33.169
MAF:
0.156
Beta (Num):
0.107
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.103
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, acetylation.5[1], 6[2]

Ratio Explanation:

The ratio reflects altered hepatic clearance by SLCO1B1; reduced function increases plasma levels of both fatty acid-related metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function impairs hepatic clearance of numerous substrates, including uric acid and bilirubin, providing a direct causal link to gout and altered bilirubin/hematological traits (TBil, MCH, MCV).1[1], 7[2], 8[3], 9[4] The gene's role in lipid transport also explains the association with triglycerides.10[5], 11[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data