eicosenoylcarnitine (c20:1)* to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs1060870

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.188
Position:
151862661
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
10.465
Reference Allele:
A
-log10(P):
-57.344
MAF:
0.398
Beta (Num):
0.064
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.124
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, acylcarnitine metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Ratio Explanation:

This ratio may reflect the balance between mitochondrial fatty acid metabolism (numerator) and fatty acid synthesis or metabolism (denominator), potentially influenced by THEM4's thioesterase activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No direct causal link between the THEM4-regulated metabolic ratio and a specific phenotype can be established with the provided information, as no phenotype is associated.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data