ximenoylcarnitine (c26:1)* to glutarylcarnitine (c5-dc)

Numerator Metabolite

Metabolite Accession: GCST90200149
Name: ximenoylcarnitine (c26:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of glutarylcarnitine (c5-dc)
Metabolite Accession: GCST90199799
Name: glutarylcarnitine (c5-dc)
Hmdb Id: HMDB0013130
Super Pathway: NA
Sub Pathway: NA
Inchikey: NXJAXUYOQLTISD

Associated Genomic Regions

Region: rs12737375

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.355
Position:
53675532
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-15.646
Reference Allele:
T
-log10(P):
-125.373
MAF:
0.317
Beta (Num):
-0.231
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.125
SE (Den):
0.016
No CNV overlap
rQTL cluster:
162
Reaction Distance:
NA
Closest Genes:
CPT2 C1orf123 MAGOH LRP8 SLC1A7

LLM Analysis

Numerator Metabolite Explanation:

Very-long-chain fatty acid oxidation

Denominator Metabolite Explanation:

Amino acid (lysine, tryptophan) degradation3[1], 4[2]

Ratio Explanation:

The ratio may reflect CPT2's reverse activity on acyl-CoAs. Reduced CPT2 function could alter the balance between fatty acid and amino acid catabolism byproducts.5[1], 6[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data