arachidonoylcarnitine (c20:4) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs2229738

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.316
Position:
68562328
SE (Ratio):
0.030
Effect Allele:
T
Z-score (Ratio):
10.391
Reference Allele:
C
-log10(P):
-56.558
MAF:
0.070
Beta (Num):
0.238
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
-0.078
SE (Den):
0.030
No CNV overlap
rQTL cluster:
57
Reaction Distance:
NA
Closest Genes:
CPT1A MTL5 MRPL21 GAL IGHMBP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport and mitochondrial beta-oxidation.5[1]

Denominator Metabolite Explanation:

Fatty acid transport and mitochondrial beta-oxidation.6[1], 7[2]

Ratio Explanation:

This ratio reflects the relative metabolism and mitochondrial uptake of arachidonic acid (C20:4) versus palmitic acid (C16) via CPT1A-mediated transport for beta-oxidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

CPT1A variants can alter its enzymatic function, impacting fatty acid oxidation. This dysregulation affects systemic lipid levels (Triglycerides, HDL-C) and hematological traits (MCH, MCV, Platelet count), likely due to changes in energy metabolism and hepatic function.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:CPT1A

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data