arachidonoylcarnitine (c20:4) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2229738

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.283
Position:
68562328
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
10.868
Reference Allele:
C
-log10(P):
-61.678
MAF:
0.070
Beta (Num):
0.238
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
-0.045
SE (Den):
0.029
No CNV overlap
rQTL cluster:
57
Reaction Distance:
NA
Closest Genes:
CPT1A MTL5 MRPL21 GAL IGHMBP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport and beta-oxidation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid transport and beta-oxidation.6[1], 8[2]

Ratio Explanation:

The ratio reflects the relative carnitine conjugation of arachidonic and oleic acid by CPT1A, indicating altered substrate flux into mitochondrial fatty acid oxidation.3[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced CPT1A activity alters mitochondrial fatty acid oxidation, impacting circulating lipid levels, including triglycerides and HDL-cholesterol, which are established cardiovascular risk factors.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:CPT1A

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data