arachidonoylcarnitine (c20:4) to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.505
Position:
61579463
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-21.337
Reference Allele:
A
-log10(P):
-230.924
MAF:
0.336
Beta (Num):
-0.269
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.236
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Polyunsaturated fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity, representing the conversion of precursor fatty acids (linoleic/linolenic) to the downstream product, arachidonic acid (a pro-inflammatory precursor).1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 activity alter the balance of pro- and anti-inflammatory long-chain PUFAs, influencing inflammatory and metabolic conditions like IBD, asthma, and dyslipidemia.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data