arachidonoylcarnitine (c20:4) to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*

Numerator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Denominator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.536
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-23.976
Reference Allele:
A
-log10(P):
-290.823
MAF:
0.342
Beta (Num):
-0.267
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.270
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation, Arachidonic acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.5[1]

Ratio Explanation:

This ratio reflects the activity of FADS desaturase enzymes, comparing an arachidonic acid product (arachidonoylcarnitine) with a phosphatidylcholine containing precursor fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid (PUFA) levels.1[1], 6[2] Elevated arachidonic acid (a pro-inflammatory precursor) can increase the numerator, linking to inflammatory phenotypes like cholelithiasis and diabetes, which are associated with altered lipid metabolism and inflammation.7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data