arachidonoylcarnitine (c20:4) to dihomo-linoleoylcarnitine (c20:2)*

Numerator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Denominator Metabolite

Metabolite Accession: GCST90200144
Name: dihomo-linoleoylcarnitine (c20:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.307
Position:
61569830
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-22.566
Reference Allele:
C
-log10(P):
-257.949
MAF:
0.338
Beta (Num):
-0.266
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.040
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1]

Ratio Explanation:

The ratio reflects the efficiency of FADS1 and FADS2 in converting less saturated C20:2 to the pro-inflammatory precursor arachidonic acid (from C20:4).1[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid balance, affecting arachidonic acid levels.1[1], 6[2] This dysregulates inflammatory pathways and lipid metabolism, increasing risk for conditions like asthma, cholelithiasis, and hypercholesterolemia which are observed among the associated phenotypes.7[3], 3[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data