5-dodecenoylcarnitine (c12:1) to 3-hydroxymyristate

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs6684114

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.122
Position:
151928715
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
7.972
Reference Allele:
A
-log10(P):
-34.092
MAF:
0.317
Beta (Num):
0.064
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Lipid A synthesis.7[1], 8[2], 9[3]

Ratio Explanation:

Increased THEM4 activity may elevate 5-dodecenoylcarnitine by cleaving its CoA ester while reducing 3-hydroxymyristate, an intermediate in another fatty acid pathway.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

THEM4 expression is associated with diverticular disease.10[1], 11[2] Altered THEM4 activity can disrupt mitochondrial fatty acid metabolism and cellular signaling, potentially affecting colonic tissue integrity and contributing to the development of diverticula.3[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data