5-dodecenoylcarnitine (c12:1) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.124
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.875
Reference Allele:
G
-log10(P):
-51.286
MAF:
0.319
Beta (Num):
0.061
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.064
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport/beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect THEM4 activity, which hydrolyzes the common precursor dodecenoyl-CoA, thereby increasing free 5-dodecenoate (denominator) and decreasing substrate for 5-dodecenoylcarnitine (numerator) synthesis.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype association was provided; therefore, a causal link between THEM4, the metabolite ratio, and a phenotype cannot be established at this time.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data