5-dodecenoylcarnitine (c12:1) to laurylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.170
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-11.843
Reference Allele:
G
-log10(P):
-72.834
MAF:
0.173
Beta (Num):
-0.134
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.036
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.6[1], 5[2]

Ratio Explanation:

The ratio of 5-dodecenoylcarnitine (C12:1) to laurylcarnitine (C12) likely reflects the activity of Stearoyl-CoA Desaturase (SCD), which creates monounsaturated fatty acids from saturated precursors.2[1], 3[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the C12:1/C12 ratio, impacts the balance of saturated to unsaturated fatty acids.7[1], 8[2] This imbalance is linked to hypercholesterolemia and the development of cardiovascular diseases like myocardial infarction and atherosclerosis.2[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data