5-dodecenoylcarnitine (c12:1) to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90200151

Name: 5-dodecenoylcarnitine (c12:1)

Hmdb Id: HMDB13326

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200187

Name: tetradecadienoate (14:2)*

Hmdb Id: HMDB0000560

Super Pathway: NA

Sub Pathway: NA

Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.184

Position:

151879761

SE (Ratio):

0.014

Effect Allele:

Z-score (Ratio):

13.584

Reference Allele:

-log10(P):

-95.099

MAF:

0.319

Beta (Num):

0.061

Novel Locus:

SE (Num):

0.016

Beta (Den):

-0.123

SE (Den):

0.016

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

An increased ratio of 5-dodecenoylcarnitine (C12:1) to tetradecadienoate (14:2) could reflect altered thioesterase activity, affecting the balance between fatty acid beta-oxidation and omega-oxidation pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between the genetic factors, the metabolite ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data