5-dodecenoylcarnitine (c12:1) to stearate (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.231
Position:
102075479
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-11.150
Reference Allele:
G
-log10(P):
-64.811
MAF:
0.173
Beta (Num):
-0.134
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.8[1], 9[2], 10[3], 11[4], 12[5]

Ratio Explanation:

The ratio of 5-dodecenoylcarnitine to stearate may reflect the activity of SCD, where higher SCD activity leads to increased desaturation of stearate, potentially influencing this ratio.1[1], 3[2], 13[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SCD activity can lead to an accumulation of saturated fatty acids like stearate and a decrease in monounsaturated fatty acids, which is associated with an increased risk of cardiovascular diseases such as myocardial infarction and atherosclerosis.14[1], 15[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data