5-dodecenoylcarnitine (c12:1) to palmitate (16:0)

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.180
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-9.617
Reference Allele:
G
-log10(P):
-48.748
MAF:
0.173
Beta (Num):
-0.134
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid desaturation, fatty acid oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, fatty acid oxidation.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects Stearoyl-CoA Desaturase (SCD) activity, indicating the rate of monounsaturated fatty acid synthesis from saturated fatty acid precursors.1[1], 2[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation likely alters SCD activity, reflected by the ratio. This dysregulation of fatty acid saturation contributes to cardiometabolic phenotypes like atherosclerosis and myocardial infarction by impacting lipid profiles, membrane fluidity, and inflammatory pathways.2[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:[SCD]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data