5-dodecenoylcarnitine (c12:1) to pentadecanoate (15:0)

Numerator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.176
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.761
Reference Allele:
G
-log10(P):
-40.788
MAF:
0.173
Beta (Num):
-0.134
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio may reflect the balance between fatty acid breakdown for energy and the synthesis and storage of fatty acids, potentially indicating SCD enzyme activity.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene expression influences the balance of fatty acids.1[1], 3[2] Altered lipid metabolism, potentially indicated by this ratio, is associated with an increased risk for cardiovascular diseases like myocardial infarction and atherosclerosis, which are listed as associated phenotypes.5[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data