hydroxy-cmpf* to xanthurenate

Numerator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs1183200

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.217
Position:
25818646
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
10.256
Reference Allele:
C
-log10(P):
-55.155
MAF:
0.445
Beta (Num):
0.109
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Furan fatty acid metabolism6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Tryptophan metabolism9[1], 10[2], 11[3]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing both furan fatty acid and tryptophan metabolism, though a direct transport relationship is unproven.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's primary role in transporting uric acid provides a direct link to the observed phenotype of altered serum uric acid levels. Variations in this gene likely impact its transport efficiency, leading to changes in circulating urate and contributing to associated hematological phenotypes.4[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data