hydroxy-cmpf* to n-acetylphenylalanine

Numerator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.257
Position:
25809069
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
11.724
Reference Allele:
G
-log10(P):
-71.419
MAF:
0.445
Beta (Num):
0.110
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.148
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Furan fatty acid metabolism, Omega-3 fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Phenylalanine metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

A higher ratio may indicate impaired clearance of the uremic toxin CMPF relative to N-acetylphenylalanine, potentially due to altered SLC17A4 transporter function.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC17A4 function can disrupt the excretion of the uremic toxin CMPF, contributing to renal stress (indicated by sCr, UA) and consequently impacting hematological parameters, as uremic toxins are known to suppress erythropoiesis.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data