3-hydroxyoleoylcarnitine to 3-hydroxyoctanoate

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.160
Position:
151879761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
10.048
Reference Allele:
G
-log10(P):
-53.028
MAF:
0.319
Beta (Num):
0.040
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2]

Ratio Explanation:

The ratio of 3-hydroxyoleoylcarnitine to 3-hydroxyoctanoate likely reflects the relative activity of long-chain versus medium-chain fatty acid oxidation, potentially influenced by THEM4's broad substrate specificity.3[1], 4[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so no causal link between THEM4, the metabolic ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data