3-hydroxyoleoylcarnitine to 3-hydroxydecanoate

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.250
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
17.624
Reference Allele:
G
-log10(P):
-158.394
MAF:
0.319
Beta (Num):
0.040
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Ratio Explanation:

This ratio compares a long-chain acylcarnitine to a medium-chain fatty acid, both intermediates in beta-oxidation. Altered SLC22A5 function likely affects this process.1[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation, the primary energy source for various cells, including hematopoietic cells. This impairment, reflected in the metabolite ratio, may lead to the observed hematological phenotypes like altered neutrophil and platelet counts.2[1], 9[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data