3-hydroxyoleoylcarnitine to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs72939920

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.200
Position:
110762453
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
13.639
Reference Allele:
A
-log10(P):
-95.851
MAF:
0.236
Beta (Num):
-0.002
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.202
SE (Den):
0.018
No CNV overlap
rQTL cluster:
103
Reaction Distance:
NA
Closest Genes:
SLC22A16 DDO METTL24 CDK19 CDC40

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid β-oxidation

Denominator Metabolite Explanation:

Fatty acid β-oxidation

Ratio Explanation:

This ratio may reflect the activity of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) in the beta-oxidation of oleic acid. An altered ratio may indicate impaired LCHAD function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A16 function may affect intracellular carnitine levels, impacting fatty acid oxidation and leading to accumulations of intermediates that could influence bilirubin metabolism, red blood cell volume (MCV), and glucose metabolism (HbA1c), though the direct mechanisms are not well-established.

Phenotype Driver:

Gene-centric:SLC22A16

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data