dodecenedioate (c12:1-dc)* to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs61741519

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.358
Position:
47325357
SE (Ratio):
0.033
Effect Allele:
G
Z-score (Ratio):
-10.738
Reference Allele:
A
-log10(P):
-60.256
MAF:
0.113
Beta (Num):
-0.148
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.210
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4B1 CYP4A11 CYP4X1 EFCAB14 ATPAF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may represent a balance between endogenous fatty acid metabolism and the detoxification of xenobiotic compounds, both potentially influenced by CYP4 family enzymes.10[1], 1[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype link can be established as no associated phenotypes were provided in the input data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data