dodecenedioate (c12:1-dc)* to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.225
Position:
25802083
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-13.699
Reference Allele:
T
-log10(P):
-96.673
MAF:
0.445
Beta (Num):
-0.061
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered renal transport of these dicarboxylic acids, possibly due to the variant SLC17A4 transporter's modified function or substrate competition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 variant likely alters renal transport of urate and dicarboxylic acids, directly impacting serum uric acid and creatinine. This may secondarily affect erythrocyte indices (MCH, MCHC, Hb) through changes in renal function or systemic oxidative stress.1[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data