heptenedioate (c7:1-dc)* to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Metabolite Accession: GCST90200163
Name: heptenedioate (c7:1-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.134
Position:
25809069
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
7.770
Reference Allele:
G
-log10(P):
-32.476
MAF:
0.445
Beta (Num):
0.062
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.072
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Fatty acid dicarboxylate metabolism.3[1]

Denominator Metabolite Explanation:

Denominator Pathway(s): Glutamine conjugation pathway.4[1]

Ratio Explanation:

Ratio Interpretation: none

Ratio Evidence:

Ratio Evidence Level: metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: Altered SLC17A4 function likely affects the transport of urate and other organic anions, leading to the observed associations with serum urate, creatinine, and hematological traits like MCH and MCHC.2[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Primary driver of phenotype link: Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data