glutamine conjugate of c7h12o2* to 3-hydroxydodecanedioate*

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydodecanedioate*
Metabolite Accession: GCST90199769
Name: 3-hydroxydodecanedioate*
Hmdb Id: HMDB0000413
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYVQCLGZFXHEGL

Associated Genomic Regions

Region: rs11211402

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.203
Position:
47392054
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
8.743
Reference Allele:
T
-log10(P):
-40.628
MAF:
0.124
Beta (Num):
0.070
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.133
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Amino acid conjugation3[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation4[1]

Ratio Explanation:

The ratio of a xenobiotic conjugate to a dicarboxylic fatty acid may reflect a shift from normal fatty acid oxidation towards alternative detoxification pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No established link between the gene, metabolite ratio, and a phenotype is available.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data