3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)** to glycochenodeoxycholate glucuronide (1)

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Metabolite Accession: GCST90200172
Name: 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Hmdb Id: HMDB0061643
Super Pathway: NA
Sub Pathway: NA
Inchikey: RIJDKRLRDVBUHJ

Denominator Metabolite

Structure of glycochenodeoxycholate glucuronide (1)
Metabolite Accession: GCST90200693
Name: glycochenodeoxycholate glucuronide (1)
Hmdb Id: HMDB0002579
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABFZMYIIUREPLL

Associated Genomic Regions

Region: rs55804858

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.493
Position:
101595065
SE (Ratio):
0.046
Effect Allele:
T
Z-score (Ratio):
10.794
Reference Allele:
C
-log10(P):
-60.873
MAF:
0.059
Beta (Num):
0.203
Novel Locus:
No
SE (Num):
0.032
Beta (Den):
-0.290
SE (Den):
0.032
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

LLM Analysis

Numerator Metabolite Explanation:

Furanoid fatty acid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Bile acid conjugation and metabolism.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects altered clearance of two ABCC2 substrates, 3-CMPFP and glycochenodeoxycholate glucuronide, due to impaired transporter function from the genetic variant.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired ABCC2 function likely reduces hepatic transport of bile acids, causing cholestasis and subsequent elevation of liver enzymes GGT, AST, and ALT.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data