glutamine conjugate of c6h10o2 (2)* to 3-hydroxyoctanoate

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs56078223

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.184
Position:
151898843
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
11.776
Reference Allele:
T
-log10(P):
-72.032
MAF:
0.294
Beta (Num):
0.066
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism, Glutamine Metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation6[1]

Ratio Explanation:

An increased ratio may indicate altered fatty acid metabolism, where THEM4's thioesterase activity on acyl-CoAs could influence the levels of both metabolites.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The THEM4 gene, which has an eQTL colocalization, influences fatty acid metabolism.1[1], 2[2] Altered fatty acid metabolism and inflammation are implicated in diverticular disease, providing a plausible link between THEM4 function, the metabolic ratio, and the phenotype.7[3], 8[4]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data