glutamine conjugate of c6h10o2 (2)* to 3-hydroxydodecanedioate*

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydodecanedioate*
Metabolite Accession: GCST90199769
Name: 3-hydroxydodecanedioate*
Hmdb Id: HMDB0000413
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYVQCLGZFXHEGL

Associated Genomic Regions

Region: rs57025390

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.203
Position:
47412477
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
8.529
Reference Allele:
C
-log10(P):
-38.754
MAF:
0.123
Beta (Num):
0.065
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.138
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

Region: rs56078223

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.140
Position:
151898843
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
8.215
Reference Allele:
T
-log10(P):
-36.090
MAF:
0.294
Beta (Num):
0.066
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.074
SE (Den):
0.018
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glutamine conjugation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Dicarboxylic acid synthesis.5[1], 6[2]

Ratio Explanation:

The ratio may reflect altered fatty acid and xenobiotic metabolism, but direct evidence connecting these metabolites and genes is lacking.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in CYP4B1 and eQTL in THEM4 are associated with diverticular disease.7[1], 8[2] Both genes are involved in fatty acid metabolism, and altered lipid metabolism may contribute to inflammation and structural changes in the colon wall seen in diverticular disease.1[3], 2[4], 7[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data