glutamine conjugate of c6h10o2 (2)* to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs1177442

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.220
Position:
25809069
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-13.056
Reference Allele:
G
-log10(P):
-88.033
MAF:
0.444
Beta (Num):
-0.056
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic detoxification, Glutamine conjugation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect altered transporter function (SLC17A4) influencing substrates for glutamine conjugation and fatty acid oxidation, pathways regulated by ACOT enzymes.11[1], 1[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC17A4 function directly contributes to hyperuricemia and gout by reducing urate excretion.4[1], 5[2], 13[3] The altered metabolic ratio is likely a downstream biomarker of systemic metabolic shifts, including fatty acid and amino acid handling, associated with gout and altered transporter function.8[4], 6[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data