3-hydroxybutyroylglycine** to 3-hydroxyoctanoate

Numerator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.177
Position:
151879761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
9.854
Reference Allele:
G
-log10(P):
-51.076
MAF:
0.319
Beta (Num):
0.058
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine).4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

Increased THEM4 activity may deplete medium-chain acyl-CoA pools, the precursors for both metabolites, potentially altering the balance between oxidation (denominator) and detoxification via glycine conjugation (numerator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Increased THEM4 expression (via eQTL) likely alters fatty acid metabolism in colonocytes. This metabolic disruption, reflected by the ratio, may impact gut inflammation and barrier integrity, contributing to diverticular disease risk.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data