glycine conjugate of c10h14o2 (1)* to 3-hydroxyoctanoate

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.223
Position:
151879761
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
10.628
Reference Allele:
G
-log10(P):
-59.075
MAF:
0.319
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Conjugation

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation4[1], 5[2], 6[3]

Ratio Explanation:

The ratio may reflect THEM4 activity; lower THEM4 could shunt acyl-CoAs from beta-oxidation (decreasing 3-hydroxyoctanoate) toward conjugation (increasing the glycine conjugate of c10h14o2).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetically-driven variation in THEM4 likely alters colonic fatty acid metabolism and energy homeostasis.2[1], 7[2] This metabolic dysregulation, reflected by the ratio, may contribute to the inflammation and pathogenesis of diverticular disease of the intestine.7[3], 8[4]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data