glycine conjugate of c10h14o2 (1)* to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs11204915

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.301
Position:
151882826
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
14.545
Reference Allele:
T
-log10(P):
-108.692
MAF:
0.400
Beta (Num):
0.117
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.184
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism, Glycine Conjugation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation.7[1]

Ratio Explanation:

The ratio likely reflects flux through mitochondrial medium-chain fatty acid metabolism, balancing beta-oxidation (denominator) against the hydrolysis and subsequent conjugation of acyl-CoAs (numerator) by THEM4.1[1], 7[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic regulation via THEM4 likely alters fatty acid metabolism, reflected in this ratio. No associated phenotype was provided to establish a causal link.1[1], 8[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data