glycine conjugate of c10h14o2 (1)* to tetradecanedioate (c14-dc)

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs11211406

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.301
Position:
47413786
SE (Ratio):
0.027
Effect Allele:
C
Z-score (Ratio):
10.985
Reference Allele:
A
-log10(P):
-62.971
MAF:
0.209
Beta (Num):
0.147
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.154
SE (Den):
0.019
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation; Glycine conjugation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

This ratio likely reflects the balance of omega-oxidation activity by CYP4 enzymes on C10 versus C14 fatty acid substrates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data