glycine conjugate of c10h14o2 (1)* to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.402
Position:
47389613
SE (Ratio):
0.034
Effect Allele:
T
Z-score (Ratio):
11.920
Reference Allele:
C
-log10(P):
-73.750
MAF:
0.128
Beta (Num):
0.201
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.201
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, amino acid catabolism.9[1], 10[2], 11[3]

Ratio Explanation:

This ratio may reflect altered CYP4B1 activity, impacting the balance between the metabolism of a xenobiotic-derived glycine conjugate and pimeloylcarnitine/3-methyladipoylcarnitine from fatty acid/amino acid breakdown.1[1], 12[2], 13[3], 11[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data is provided, so a causal link cannot be established between the CYP4B1 variant, the metabolic ratio, and a specific phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data