glycine conjugate of c10h14o2 (1)* to glycine conjugate of c10h12o2*

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs111770290

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.532
Position:
96728688
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
18.120
Reference Allele:
T
-log10(P):
-167.296
MAF:
0.064
Beta (Num):
0.390
Novel Locus:
No
SE (Num):
0.032
Beta (Den):
-0.142
SE (Den):
0.037
No CNV overlap
rQTL cluster:
72
Reaction Distance:
NA
Closest Genes:
CYP2C9 CYP2C8 CYP2C19 C10orf129 CYP2C18

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation pathway.

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation pathway.

Ratio Explanation:

This ratio reflects the CYP2C-mediated dehydrogenation of a glycine-conjugated C10H14O2 compound to its corresponding C10H12O2 conjugate; a higher ratio suggests reduced enzyme activity.

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced CYP2C9 activity, indicated by an elevated metabolite ratio, can impair the metabolism of drugs like NSAIDs.7[1], 8[2], 9[3] This increases drug exposure and toxicity, elevating the risk of developing gastroduodenal ulcers, a known side effect of NSAIDs.7[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data