glycine conjugate of c10h14o2 (1)* to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs10788817

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.242
Position:
151882856
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
11.686
Reference Allele:
G
-log10(P):
-70.968
MAF:
0.400
Beta (Num):
0.117
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.125
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Glycine conjugation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.3[1]

Ratio Explanation:

The ratio likely indicates the balance between glycine conjugation of medium-chain fatty acyl-CoAs and beta-oxidation of long-chain fatty acyl-CoAs, modulated by THEM4 thioesterase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data provided, precluding the establishment of a causal link between the THEM4-modulated metabolic ratio and a clinical outcome.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data