glutamine conjugate of c6h10o2 (1)* to 3-hydroxyoctanoate

Numerator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs12239945

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.163
Position:
151975094
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
9.482
Reference Allele:
A
-log10(P):
-47.442
MAF:
0.308
Beta (Num):
0.043
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.120
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 S100A11 TCHHL1 THEM4 TCHH

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, detoxification.2[1], 3[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Ratio Explanation:

The ratio reflects a shift between fatty acid oxidation and detoxification pathways, potentially modulated by THEM4's regulation of the common acyl-CoA substrate pool.1[1], 4[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered THEM4 expression likely dysregulates colonic fatty acid metabolism, evidenced by the ratio shift. This metabolic disruption may impair gut barrier integrity, contributing to the development of diverticular disease.1[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data