glyco-beta-muricholate** to DHEAS

Numerator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.312
Position:
99075038
SE (Ratio):
0.060
Effect Allele:
C
Z-score (Ratio):
21.808
Reference Allele:
T
-log10(P):
-241.110
MAF:
0.037
Beta (Num):
0.889
Novel Locus:
No
SE (Num):
0.043
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Steroidogenesis, Adrenal androgen biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio may reflect a trade-off between bile acid synthesis and steroidogenesis, both energy-demanding pathways influenced by mitochondrial ATP production.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered mitochondrial energetics due to ATP5J2 variation could shift cholesterol metabolism from steroid production (DHEAS) to bile acid synthesis, influencing inflammatory and metabolic phenotypes like CRP, uric acid, and BMI.8[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:ATP5J2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data