n,n,n-trimethyl-alanylproline betaine (tmap) to n1-methylinosine

Numerator Metabolite

Structure of n,n,n-trimethyl-alanylproline betaine (tmap)
Metabolite Accession: GCST90200181
Name: n,n,n-trimethyl-alanylproline betaine (tmap)
Hmdb Id: HMDB0240365
Super Pathway: NA
Sub Pathway: NA
Inchikey: KXONJPJIFNGMCN

Denominator Metabolite

Structure of n1-methylinosine
Metabolite Accession: GCST90199761
Name: n1-methylinosine
Hmdb Id: HMDB0002721
Super Pathway: NA
Sub Pathway: NA
Inchikey: WJNGQIYEQLPJMN

Associated Genomic Regions

Region: rs11516732

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.174
Position:
61405043
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
8.566
Reference Allele:
T
-log10(P):
-39.077
MAF:
0.164
Beta (Num):
0.069
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.105
SE (Den):
0.020
No CNV overlap
rQTL cluster:
74
Reaction Distance:
NA
Closest Genes:
SLC16A9 CCDC6 FAM13C C10orf40 ANK3

LLM Analysis

Numerator Metabolite Explanation:

Dipeptide metabolism, Betaine metabolism.5[1]

Denominator Metabolite Explanation:

tRNA degradation, Purine metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect SLC16A9 transport activity (tmap) relative to purine turnover (n1-methylinosine), a pathway central to gout and uric acid production.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the transporter SLC16A9 are associated with gout and serum uric acid.1[1], 2[2], 3[3] This ratio may reflect SLC16A9's role in transporting molecules like betaines while also correlating with purine breakdown products that lead to the gout phenotype.

Phenotype Driver:

Gene-centric:SLC16A9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data