glycine conjugate of c10h12o2* to 3-hydroxyoctanoate

Numerator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.218
Position:
151879761
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
9.445
Reference Allele:
G
-log10(P):
-47.086
MAF:
0.324
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid conjugation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

Ratio likely reflects THEM4 activity influencing the balance between fatty acid beta-oxidation (denominator) and alternative acyl-CoA metabolism like glycine conjugation (numerator).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered THEM4 expression likely modulates fatty acid metabolism and inflammation.1[1], 2[2], 5[3] This can affect intestinal energy balance and inflammatory responses, contributing to the risk of diverticular disease, which is linked to inflammation and metabolic shifts.5[4], 6[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data