glycine conjugate of c10h12o2* to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs2338201

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.228
Position:
151845650
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
10.068
Reference Allele:
C
-log10(P):
-53.227
MAF:
0.403
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.125
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Glycine Conjugation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty Acid Metabolism, Beta-Oxidation.6[1], 7[2]

Ratio Explanation:

This ratio likely reflects the balance between fatty acid metabolism pathways, where THEM4's hydrolysis of acyl-CoAs can influence substrates for both conjugation and oxidation.1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype is associated, so a causal link cannot be established. THEM4's role in regulating fatty acid metabolism likely influences this ratio.1[1], 6[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data