glycine conjugate of c10h12o2* to dodecadienoate (12:2)*

Numerator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7523082

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.222
Position:
151848126
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
9.915
Reference Allele:
T
-log10(P):
-51.679
MAF:
0.404
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.119
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylalanine metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Dicarboxylate fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio likely reflects THEM4 activity on acyl-CoA precursors of both metabolites, modulating the balance between fatty acid and potential xenobiotic metabolism.1[1], 4[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data