n-acetyl-2-aminooctanoate* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs73067080

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.208
Position:
21388829
SE (Ratio):
0.026
Effect Allele:
C
Z-score (Ratio):
-7.867
Reference Allele:
T
-log10(P):
-33.252
MAF:
0.165
Beta (Num):
-0.101
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.108
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 SLCO1A2 RP11-125O5.2 IAPP SLCO1B7

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio likely reflects altered SLCO1B1-mediated hepatic uptake; variants affect transport of various organic anions, potentially including n-acetyl-2-aminooctanoate and lysophospholipids, altering their relative plasma concentrations.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the transport of bilirubin and urate, linking it to elevated total bilirubin and gout.3[1], 8[2], 9[3], 10[4] Altered transporter activity likely affects the ratio, which is correlated with triglyceride and red blood cell indices.8[5], 10[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data