n-acetyl-2-aminooctanoate* to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of n-acetyl-2-aminooctanoate*
Metabolite Accession: GCST90200183
Name: n-acetyl-2-aminooctanoate*
Hmdb Id: HMDB0059745
Super Pathway: NA
Sub Pathway: NA
Inchikey: JJGNMSOJTSABGA

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.218
Position:
21343833
SE (Ratio):
0.027
Effect Allele:
C
Z-score (Ratio):
-8.018
Reference Allele:
A
-log10(P):
-34.464
MAF:
0.156
Beta (Num):
-0.105
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.113
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.5[1], 6[2], 7[3], 8[4], 9[5]

Ratio Explanation:

Reduced SLCO1B1 function may alter the transport and metabolism of fatty acids and their derivatives, affecting the balance between these two lipid metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function is linked to altered bilirubin and lipid metabolism, which are associated with the coronary atherosclerosis phenotype.10[1], 11[2], 12[3], 13[4], 14[5], 15[6], 16[7], 17[8], 18[9], 19[10], 20[11], 21[12] Altered fatty acid metabolism may also contribute to the observed blood parameter phenotypes.10[13]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data