3-formylindole to xanthurenate

Numerator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs9461218

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.186
Position:
25818755
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-9.525
Reference Allele:
G
-log10(P):
-47.857
MAF:
0.236
Beta (Num):
-0.082
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.104
SE (Den):
0.018
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan-Indole pathway4[1]

Denominator Metabolite Explanation:

Tryptophan (Kynurenine) metabolism5[1], 6[2]

Ratio Explanation:

The ratio reflects tryptophan metabolism dynamics, where both metabolites are downstream products, potentially influenced by transporters like SLC17A1 that handle organic anions.2[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A1 function likely modifies urate transport, directly impacting Uric Acid levels.1[1], 8[2] Concurrently, changes in tryptophan metabolism, which is linked to hematopoiesis, could influence red blood cell parameters, though the direct connection to this specific ratio is not established.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:SLC17A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data