3-formylindole to n6-carbamoylthreonyladenosine

Numerator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Denominator Metabolite

Structure of n6-carbamoylthreonyladenosine
Metabolite Accession: GCST90199762
Name: n6-carbamoylthreonyladenosine
Hmdb Id: HMDB0041623
Super Pathway: NA
Sub Pathway: NA
Inchikey: GYCVHQYQICRFAX

Associated Genomic Regions

Region: rs34396849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.262
Position:
28250955
SE (Ratio):
0.033
Effect Allele:
C
Z-score (Ratio):
-7.975
Reference Allele:
A
-log10(P):
-34.115
MAF:
0.093
Beta (Num):
-0.136
Novel Locus:
Yes ✔️
SE (Num):
0.025
Beta (Den):
0.126
SE (Den):
0.024
No CNV overlap
rQTL cluster:
110
Reaction Distance:
NA
Closest Genes:
PGBD1 NKAPL ZKSCAN4 ZSCAN31 ZSCAN9

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

tRNA modification pathway.8[1]

Ratio Explanation:

The ratio may reflect a shift in cellular resources between tryptophan metabolism and tRNA modification, potentially influenced by PGBD1's regulatory role, but a direct link is unclear.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The PGBD1 gene's role in regulating gene expression may influence immune system function, leading to a predisposition to autoimmune conditions like Grave's disease and IgA nephropathy.

Phenotype Driver:

Gene-centric:PGBD1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data