3-formylindole to 8-methoxykynurenate

Numerator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Denominator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Associated Genomic Regions

Region: rs9393671

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.188
Position:
25789189
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
8.372
Reference Allele:
C
-log10(P):
-37.411
MAF:
0.302
Beta (Num):
0.099
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.088
SE (Den):
0.018
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Tryptophan metabolism6[1], 7[2], 8[3]

Ratio Explanation:

3-formylindole is a product of tryptophan degradation, while 8-methoxykynurenate is part of the kynurenine pathway, also from tryptophan. The ratio reflects different tryptophan metabolism branches.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A3 gene is a transporter for uric acid.1[1], 2[2], 3[3], 9[4] Both metabolites derive from tryptophan, and tryptophan metabolism is linked to hematological parameters and uric acid, suggesting a complex interaction between the gene's function and metabolic state affecting these phenotypes.10[5]

Phenotype Driver:

Gene-centric:SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data