8-methoxykynurenate to xanthurenate

Numerator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.201
Position:
25802083
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
11.064
Reference Allele:
T
-log10(P):
-63.842
MAF:
0.448
Beta (Num):
0.094
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.107
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan Metabolism / Kynurenine Pathway.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Tryptophan Metabolism / Kynurenine Pathway.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the relative activity of different branches of the kynurenine pathway; its link to a renal transporter suggests a shared clearance mechanism.12[1], 13[2], 14[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 variant likely alters renal transport, impacting the clearance of kynurenine pathway metabolites (the ratio), uric acid, and creatinine.12[1], 2[2] This shared renal mechanism plausibly links the gene, ratio, and the observed renal and hematological (e.g., MCH, Hb) phenotypes.13[3], 15[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data